A team of scientists from the University of North Carolina conducted a unique study in which it was found that women who are overweight have a higher risk of one of the most aggressive forms of breast cancer – basal carcinoma.
Experts describe the biological mechanisms of the process, because of which fullness women creates a very favorable environment for the emergence of basal breast cancer.
Similar studies were conducted earlier. In the course of this study, the experts confirmed that there is a correlation between obesity and the molecular mechanisms of the pathological process. An important task of scientists was to identify biomarkers linking overweight and the development of breast tumors.
Breast cancer is a heterogeneous disease with different subtypes and varieties. One of the most aggressive forms of breast cancer – basal carcinoma is diagnosed in 15-20% of women suffering from breast cancer. Most often, this type of tumor is found in young women. This kind of tumor is different in that it's pretty poorly responsive to treatment (chemotherapy, radiation, and hormone) and is mostly a poor prognosis.
Previously, experts called several reasons that increase the risk of developing breast cancer in obesity. The most important factor contributing to the development of the disease, named hyperestrogenemia characteristic of overweight women. The uniqueness of this study is that the experts focused on the role played in the emergence of breast cancer, breast tissue called stroma. Scientists call this material "soil", which appears cancer. Also, scientists have confirmed that in postmenopausal women the risk of obesity increases significantly.
Experts recommend women to monitor their weight, if necessary, to reduce caloric intake and improve the quality of the food consumed by increasing consumption of fresh fruits and vegetables and lowering intake of animal fats. Scientists their study clearly showed that the measures taken by public health authorities for the prevention of obesity in women can be one of the most important ways of preventing such aggressive diseases like basal carcinoma of the breast.